For many people, hair loss can have a significant negative impact on self-confidence and self-esteem as it affects not only the physical appearance but also the mental health of a person. During the last decade, cosmetic surgery has sought to ease this stress. Hair transplantation remains an intrusive process for hair replacement that is also very expensive, while the effectiveness of hair loss oral medication is uncertain. There is a massive market for any new treatment that may effectively prevent baldness and treat alopecia.

In Japan, adipose-derived stem cells were employed in clinical trials for hair loss regrowth. One of the most breakthroughs in hair loss treatment was when scientists were able to isolate adipose-derived stem cells (ADSCs) from cytokines, which are proteins found in blood cells. The cells were transformed into ADSC-CM, a hypoxia-boosted condition. This implies that removing oxygen from cells stimulates growth factors, making it more effective for treating hair loss. The procedure was advanced by employing AAPE (Advanced Adipose-Derived Stem Cell Protein Extract) on those who were experiencing hair loss.

AAPE is the process of transforming adipose-derived stem cells into lyophilized forms. The clinical experiment started with injecting three to four milliliters of AAPE into the scalp of the alopecia patients. The injections were given once a month and had to be given six to eight times. The active phase of hair development showed significant results after the first two to three sessions, with the hair rapidly replicating. Increasing the number of treatments resulted in new hair growth, and patients experienced more noticeable positive outcomes over time.

Conventional techniques of hair loss treatment have not yielded the desired results for many. Hair transplants are not for everyone as they are expensive and often painful methods of hair restoration, while only a few oral medications are approved for safe use, and can be ineffective. As a consequence, there has been an ongoing struggle to find more effective and practical solutions to hair growth. With the regeneration treatment from the AAPE method, there is some promise. This procedure is attracting the interest of Japanese people and could become more commonly available in other parts of the world. With the evidence from the clinical trials in Japan, the AAPE method for hair restoration shows that it is a safe and effective method. It might not deliver rapid results, but it does promote hair regrowth over time.