Scientific Articles

Micro-Current Stimulation Has Potential Effects of Hair Growth-Promotion on Human Hair Follicle-Derived Papilla Cells and Animal Model – Click Here

Self-Activated Electrical Stimulation for Effective Hair Regeneration via a Wearable Omnidirectional Pulse Generator – Click Here

Self-Activated Electrical Stimulation for Effective Hair Regeneration via a Wearable Omnidirectional Pulse Generator – Click Here

Researchers regrow hair on wounded skin – Click Here

Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells – Click Here

Cell-enriched fat may represent alternative for treating pattern hair loss – Click Here

Safety and efficacy analysis of liposomal insulin-like growth factor-1 in a fluid gel formulation for hair-loss treatment in a hamster model – Click Here

Hair Regeneration Therapy: Application of Adipose-Derived Stem Cells – Click Here

Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis – Click Here

SDF-1 (stem cell homing factor)

 

Bioengineering the Hair Follicle – NCBI – National Institutes of Health

www.ncbi.nlm.nih.gov/…

 

Low current electrical stimulation upregulates cytokine expression in …

www.ncbi.nlm.nih.gov/…

 

Cure for baldness? Stem cells bring hope – Medical News Today

www.medicalnewstoday.com/articles/271898.php

 

Shrinking Stem Cells Are the Real Reason for Hair Loss | TIME

time.com/4209749/hair–loss–stem–cells/

 

Studies indicate it’s possible to use stem cells to cure baldness

www.cnbc.com/…/studies-indicate-its-possible-to-use-stem–cells-to…

 

Follistatin

 

A role of follistatin in the control of hair follicle morphogenesis

www.fasebj.org/content/early/…/fj.02-0247fje.full.pd…

 

[PDF]Nouricel Hair Re-Growth & Neogenesis – ZacksInvest

https://www.zacksinvest.com/…/HSC%20Application%20Overview.pdf

 

Regenerative Hair Waves in Aging Mice and Extra-Follicular …

www.sciencedirect.com/science/…/S0022202X15369372

 

The Thinning Top: Why Old People Have Less Hair – Nature

www.nature.com/jid/journal/v134/n8/pdf/jid2014172a.pdf?WT…

http://www.des-company.com/wp-content/uploads/2014/05/Zimber-et-al-2011.pdf

http://www.ncbi.nlm.nih.gov/pubmed/22052313

 

 

IGF-1

 

Exogenous IGF-1 promotes hair growth by stimulating cell proliferation …

www.sciencedirect.com/science/…/S1096637414000239

 

IGF-1 | Theory | JAPAN HAIR GROWTH CONSULTANTS

www.jhgc.com.sg/theory/igf–1/index.html

 

Insulin-like Growth Factor 1 (IGF-1) | The End of Hair Loss and Balding …

www.hairlosscure2020.com/insulin-like-growth-factor-1–igf–1/

 

LEAKED: Break-through Hair Loss Treatment with Unexpected …

www.nicehair.org/breakthrough-hair–loss-cure-based-on-3-combined-gr…

http://www.ncbi.nlm.nih.gov/pubmed/10673454

 

HGF

 

Hepatocyte growth factor (HGF) activator expressed in hair follicles is …

www.ncbi.nlm.nih.gov/…

Hair Regeneration Treatment Using Adipose-Derived Stem Cell …

www.ncbi.nlm.nih.gov/…

 
[PDF]The Latest Advance in Hair Regeneration Therapy Using Proteins …

www.orangecountyhairrestoration.org/…/ADSC-hair–restoration.pdf 

Reversing Age-Related Hair Loss and Restoring Healthy Hair Growth …

nutritionreview.org/…/reversing-age-related-hair–loss-and-restoring-healt…

http://www.sciencedirect.com/science/article/pii/S0923181100001249

https://www.youtube.com/watch?v=aWK6qJFvWoM

http://www.ncbi.nlm.nih.gov/pubmed/10674388

http://www.fasebj.org/content/14/2/319.full

 

 

eNOS and VEGF

 

Interesting study about prolactin, VEGF and … – Regrowth.com

www.regrowth.com › Hair Loss Forums › General Hair Loss 

Arnebin-1 promotes angiogenesis by inducing eNOS, VEGF and HIF …

https://www.spandidos-publications.com/ijmm/36/3/685

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC199257/

http://www.hairloss-reversible.com/control-of-hair-growth-by-a-growth-factor-protein/

 

http://www.svijet-kose.com/dokumenti/Serum-vegf.pdf

 

https://www.sciencedaily.com/releases/2001/02/010215074636.htm

 

Activin 

 

Activin B Promotes Initiation and Development of Hair … – Karger

https://www.karger.com/Article/Pdf/356304

 

Activin B promotes initiation and development of hair follicles in mice.

www.ncbi.nlm.nih.gov/…

 

TROPOELASTIN 

 

Protein Genomics – Elastatropin® in Scalp & Hair Conditioning

https://www.proteingenomics.com/haircare.html 

What Is Elastin? | Keracyte

www.keracyte.com/index.php/site/page?view=whatIsElastin

Multiple Protein Expressions

http://www.orangecountyhairrestoration.org/webdocuments/ADSC-hair-restoration.pdf

http://www.indjst.org/index.php/indjst/article/viewFile/80263/62051

 

INVENTION TITLE

A method and apparatus for producing hair growth stimulation using bioelectric energy, topical compositions, stem cell/growth factor micro infusions and combinations thereof. By using bioelectric signaling resulting from specific protein expressions and their cellular responses to exposure to specific micro voltages.

BACKGROUND OF THE INVENTION

Problem Solved: Many people lose hair as they age.  Thin hair causes loss of self-esteem.

Other methods and devices at best increase hair coverage by 10%.

Our device controls release of SDF-1 a stem cell homing factor as well as IGF-1, HGF, EGF, Follistatin, Tropoelastin, eNOS and VEGF as well as micro infusion delivery of a 15 component hair regeneration cocktail which includes nutrient hydrogel, thus providing all the supporting element to grow a full head of hair.

DETAILED DESCRIPTION OF THE INVENTION

As stated above, many people lose hair as they age.  Thin hair causes loss of self-esteem. The invention claimed here solves this problem.

Our devices utilizes specific bioelectric signals to control release of 10 key hair regeneration proteins and for severe cases is combined with a stem cell/growth factor micro infusion pump to regenerate a full head of hair.

The claimed invention differs from what currently exists. No other product delivers a full complete combination of growth factors and stem cells necessary for complete and full hair regeneration.

This invention is an improvement on what currently exists. No other product delivers a full complete combination of growth factors and stem cells necessary for complete and full hair regeneration.

Prior art fails to address all the mechanisms necessary for complete hair regeneration.  Most current treatments have nowhere near the volume of active agent necessary to regenerate a full head of thick hair.

Our device controls release of SDF-1 a stem cell homing factor as well as IGF-1, HGF, EGF, Follistatin, Tropoelastin, eNOS and VEGF as well as micro infusion delivery of a 15 component hair regeneration cocktail which includes nutrient hydrogel, thus providing all the supporting element to grow a full head of hair.

Also, it can produce Hair regeneration.  Hair removal.  Skin regeneration.

The Version of The Invention Discussed Here Includes:

1. Brain Electroacupuncture Cap
2. Micro regeneration stimulator and connecting leads
3. Micro infusion pump
4. Bioelectric signal program SDF-1 = Stem Cell Homing Factor
5. Bioelectric signal program IGF-1
6. Bioelectric signal program HGF
7. Bioelectric signal program EGF
8. Bioelectric signal program Follistatin
9. Bioelectric signal program Tropoelastin
10. Bioelectric signal program eNOS
11. Bioelectric signal program VEGF
12. Bioelectric signal program Activin A + B
13. Hair regeneration cocktail 15 component composition
14. Bioelectric signal for cell proliferation
15. Bioelectric signal to control differentiation

Relationship Between The Components:

Brain electroacupuncture cap (1) is placed on head of patient.  (2) micro regeneration stimulator is connected to brain cap (1).  Micro infusion pump (3) is connected to brain electroacupuncture cap.  Micro stimulator runs through a program releases 10 specific proteins for specific purposes all of which work together for complete hair regeneration.  In severe cases a micro pump is filled with the HC-15 fifteen component hair regeneration cocktail comprising three types of stem cells, growth factors, nutrient hydrogel, scalp matrix and Micro RNAS as well as known topical solutions for hair regeneration. 12.  The method of claim 1 where said bioelectric signal produces  eNOS –  Alternating high-frequency (HF) and medium-frequency signals (MF) – Symmetric, biphasic, trapezoid pulses, with 400-µs pulse duration and 1.5/1-s ramp-up/ramp-down duration, respectively. HF consisted of 75 Hz pulses with 6 s on–21 s off for 15 minutes. MF consisted of 45 Hz pulses with 5 s on–12 s off for 15 minutes.   Followed by stimulation duration set as 20 min for both 1 Hz and 20 Hz stimulations. For 1 Hz stimulation, stimulation was applied for 9 sec, followed by a 1 sec silent period, a total of 1080 stimulations for 20 min. For 20 Hz stimulation, stimulation was applied for 2 sec, followed by silent period for 28 sec, a total of 1600 stimulations for 20 min.

13. The method of claim 1 where said bioelectric signal produces Activin A – 6mv at 150 HZ Monophasic square wave pulse 0.1 ms in duration current of 15 mA for 15 minutes.

How The Invention Works:

The micro hair regeneration stimulator may be used as a standalone.  Results are accelerated and enhanced with the addition of the micro infusion pump that is re-filled daily, weekly or monthly. 14.  Method of claims 1 to 13 in sequence order of VEGF, eNOS, SDF-1, Proliferation, VEGF, eNOS, HGF, IGF-1, Follistatin, Differentiation, Tropolastin, Follistatin, IGF-1, HGF, SDF-1 and repeated.

15. Method of claim 1 where bioelectric signal causes controlled expression of FGF.
16. Method of claim 1 where bioelectric signal causes controlled expression of EGF

How To Make The Invention:

The brain cap is adapted from EEG monitoring caps and electro acupuncture needles.  The micro stimulator is obtained from an OEM supplier of heart pacemakers.  The software is programmed into the stimulator with a standard programmer.  The micro pump is obtained from an OEM supplier that makes pumps for drug infusion.

The micro regeneration stimulator is essential.  The brain cap is optional.  You can use tape electrodes or standard electro acupuncture needles instead OR the signals can be transmitted by a wireless light like device.   The micro infusion pump is optional for severe cases or for accelerating results.

6. The method of claim 1 where said bioelectric signal produces – stem cell differentiation signals – (Leonhardt Signals) – 200 picoamps for 10 seconds for 1 hr + the pulse has an amplitude of 5 volts and a width of 0.5 milliseconds for 1 hr

7. The method of claim 1 where said bioelectric signal produces Follistatin – (muscle growth) production signal (Genovese + Leonhardt) – 10V @ 50 HZ and 100 HZ for 12 hrs each

8. The method of claim 1 where said bioelectric signal produces HGF – Hepatocyte growth factor (arrhythmia reduction) signal (Genovese + Leonhardt) – 3.5V stimulation in 10 second bursts, 1 burst every 30 seconds @ frequency 50 HZ

9. The method of claim 1 where said bioelectric signal produces IGF-1 (Genovese + Leonhardt) – 3mv with electric frequency of 22 Hz, and electric current of 1 mA for 15 minutes and 3ma for 15 minutes

10. The method of claim 1 where said bioelectric signal produces Tropoelastin (Genovese + Leonhardt) – 0.06?V with 50Z alternating electrical field and electric current of 1ma for 15 minutes and 3ma for 15 minutes

11. The method of claim 1 where said bioelectric signal produces RANKL nuclear factor-kappa B (NF-?B) ligand (Genovese + Leonhardt + Marchetto) – 3MV at 2/100 Hz alternating frequency with current of 3ma followed by 15 Hz, 1 Gauss EM field, consisting of 5-millisecond bursts with 5-microsecond pulses followed by 200-µs pulse duration @ 30 Hz and with current amplitude of 140 mA.

12. The method of claim 1 where said bioelectric signal produces eNOS –  Alternating high-frequency (HF) and medium-frequency signals (MF) – Symmetric, biphasic, trapezoid pulses, with 400-µs pulse duration and 1.5/1-s ramp-up/ramp-down duration, respectively. HF consisted of 75 Hz pulses with 6 s on–21 s off for 15 minutes. MF consisted of 45 Hz pulses with 5 s on–12 s off for 15 minutes.   Followed by stimulation duration set as 20 min for both 1 Hz and 20 Hz stimulations. For 1 Hz stimulation, stimulation was applied

How To Use The Invention:

The brain cap is connected to the stimulator and pump and treatment is 40 minutes 3 times a week for 8 to 36 weeks as needed. Claims (16)

1. A method for stimulating hair growth, comprising: exposing a hair growth structure to a source of narrow band of bioelectric signals, without having applied a drug, cosmeceutical, and/or chromophore to the hair growth structure;

bioelectrical signal controlled protein release to promote hair growth by maintaining the exposure of the hair growth structure to the source of narrowband of bioelectric signals for protein expression for a clinically effective duration and at a clinically effective depth to stimulate hair growth without causing skin ablation.

2. The method of claim 1 wherein said source of narrowband bioelectric signals are delivered by any one of these methods; wireless transmission, electro-acupuncture needles, conductive patches doped with hair growth promoting drugs and proteins, a conduction signal helmet or cap, a metal hair scalp tickler or any combination thereof.

3. The method of claim 1 where said bioelectric signal produces vascular endothelial growth for factor release VEGF – to promote hair growth and blood vessel sprouting growth 0.1V applied at a frequency of 50 Hz. 4.  The method of claim 1 where said bioelectric signal produces SDF-1  – Stem cell recruiting signal (the Leonhardt Signal) – 30 pulses per second with a voltage of 3.5 mV, and successively alternating currents of 700 to 1500 picoamps for one minute,  and again with 700 to 1500 picoamps for one minute +  stimulated with current of 0.25 mA, pulse duration of 40 pulses/s, pulse width of 100 µs, and frequency of 100 Hz.  5.  The method of claim 1 where said bioelectric signal produces – stem cell proliferation signal (Leonhardt-Chachques) – 15 mV and a current of 500 picoamps at 70 pulses per minute for 3 hrs + 20 pulses per minute, a pulse amplitude of from 2.5-6 volts, and a pulse width of from 0.2-0.7 milliseconds for 3 hrs

Additionally: The micro stimulator + micro pump + regeneration composition + bioelectric signaling programming may be used to regenerate any tissue or organ.

Also, it can create: Hair regeneration.  Hair removal.  Skin regeneration.

ABSTRACT

A method and apparatus for producing hair growth stimulation using bioelectric energy, topical compositions, stem cell/growth factor micro infusions and combinations thereof. By using bioelectric signaling resulting from specific protein expressions and their cellular responses to exposure to specific micro voltages. Our device controls release of SDF-1 a stem cell homing factor as well as IGF-1, HGF, EGF, Follistatin, Tropoelastin, eNOS and VEGF as well as micro infusion delivery of a 15 component hair regeneration cocktail which includes nutrient hydrogel, thus providing all the supporting element to grow a full head of hair.